反应详情

The procedure of Example 30 was employed utilizing N-t-butyl-N-benzylamine and isopropyl phosphonic dichloride. The reaction of the dilithio compound and the isopropyl phosphonic dichloride was conducted at -70° C. The crude product produced as a result of the chromatographic separation was distilled at 130° C. and 0.1 mm to yield a colorless oil. The colorless oil was slurried in petroleum ether to yield 1-isopropyl-2-t-butyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (5.8 g, 39% yield) having a melting point of 67°-70° C. and the following analysis:

1. customwas conducted at -70° C
2. customThe crude product produced as
3. customa result of the chromatographic separation
4. distillationwas distilled at 130° C.
5. custom0.1 mm to yield a colorless oil