Isopropylbenzylamine → HCID 13037511, compound

HRID 2058911Notes

Reaction equation

HRID 2058911 reaction equation
[CH:1]([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([CH3:3])[CH3:2].[CH:12]([P:15](Cl)(Cl)=[O:16])([CH3:14])[CH3:13]>>[CH:12]([P:15]1(=[O:16])[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][N:4]1[CH:1]([CH3:3])[CH3:2])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 66024IsopropylbenzylamineHCID 2793751Isopropylphosphonic dichloride2×

Product 1

HCID 13037511HCID 13037511, compoundYield 16%

Procedure

The procedure of Example 30 was employed utilizing N-isopropyl-N-benzylamine and isopropyl phosphonic dichloride. The reaction of the dilithio compound and the isopropyl phosphonic dichloride was conducted at -70° C. The crude product produced as a result of the chromatographic separation was distilled at 130° C. and 0.1 mm to yield a colorless oil. This oil was slurried in petroleum ether to yield 1,2-diisopropyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide (2.28 g, 16% yield) as a pale yellow oil having the following analysis:

Workup

  1. customwas conducted at -70° C
  2. customThe crude product produced as
  3. customa result of the chromatographic separation
  4. distillationwas distilled at 130° C.
  5. custom0.1 mm to yield a colorless oil

Sources & evidence

ORD record
ord-81e4f1d621bc4db7bc9cb1a61c91dd6d
Source dataset
uspto-grants-1982_03
Patent number
US04319913

Reaction notes

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