Water → HCID 20548773, compound

HRID 2058945Notes

Reaction equation

HRID 2058945 reaction equation
Cl.Cl.[CH2:3]([C:9]1[NH:10][NH:11][C:12]2[N:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(N(CC)CC)C.[C:26]([Cl:34])(=[O:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.O>C(#N)C>[ClH:34].[CH2:3]([C:9]1[NH:10][N:11]([C:26](=[O:33])[C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:12]2[N:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

6

Reactant 4

HCID 962WaterHCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 20548756HCID 20548756, compound

Product 1

HCID 20548773HCID 20548773, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3 g (0.01 mole) of 3-hexyl-1,2-dihydropyrido-[3,2-e]-as-triazine dihydrochloride are reacted with 2 g (0.02 mole) of triethylamine in 60 ml of anhydrous acetonitrile under argon, thereafter 2.9 g (0.02 mole) of benzoylchloride are added to the reaction mixture which is boiled for an hour. Then the mixture is cooled, poured into water, neutralized and extracted with chloroform. The solvent is evaporated and the residue is reacted with anhydrous hydrochloric ethanol to form a salt.

Workup

  1. waitis boiled for an hour
  2. temperatureThen the mixture is cooled
  3. extractionextracted with chloroform
  4. customThe solvent is evaporated
  5. customthe residue is reacted with anhydrous hydrochloric ethanol
  6. customto form a salt

Sources & evidence

ORD record
ord-24bce9e9abe1407e8d503f8325f34b5b
Source dataset
uspto-grants-1982_03
Patent number
US04320127

Reaction notes

Loading…