Hydrochloric Acid → methyl 1,3-dithiane-2-carboxylate

HRID 2058995Notes

Reaction equation

HRID 2058995 reaction equation
[S:1]1[CH2:6][CH2:5][CH2:4][S:3][CH:2]1[C:7]([O:9][CH2:10]C)=[O:8].Cl>CO>[CH3:10][O:9][C:7]([CH:2]1[S:3][CH2:4][CH2:5][CH2:6][S:1]1)=[O:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 88552Ethyl 1,3-dithiane-2-carboxylate

Product 1

HCID 315855methyl 1,3-dithiane-2-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Dissolve 192 g (1 mole) of ethyl 1,3-dithiane-2-carboxylate in 1 L of methanol and add 5 ml of concentrated hydrochloric acid. Stir at room temperature for 18 hours. Neutralize the mixture with 1 N sodium hydroxide and remove the methanol under reduced pressure. Take up the residue in 1 L of ether, wash with water, dry over magnesium sulfate and evaporate. Distil the residue under reduced pressure to obtain methyl-1,3-dithiane-2-carboxylate.

Workup

  1. customNeutralize the mixture with 1 N sodium hydroxide and remove the methanol under reduced pressure
  2. washwash with water
  3. dry with materialdry over magnesium sulfate
  4. customevaporate
  5. customDistil the residue under reduced pressure

Sources & evidence

ORD record
ord-955a525b5e324bd48c5a47c15ed14433
Source dataset
uspto-grants-1982_03
Patent number
US04321197

Reaction notes

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