Hydrochloric Acid → HCID 12906310, compound

HRID 2059001Notes

Reaction equation

HRID 2059001 reaction equation
C(O[C:6]([N:8]([N:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1)C)=O)(C)(C)C.[ClH:19]>>[ClH:19].[CH3:6][NH:8][N:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12906308HCID 12906308, compound

Product 1

HCID 12906310HCID 12906310, compound

Procedure

To the crude N-(t-butyloxycarbonyl-N-methylamino)dihydroisoindole from the above preparation was added 25 ml of concentrated hydrochloric acid. The reaction mixture was allowed to stir for one hour. Evaporation of the mixture to dryness and recrystallization of the residue from ethanolether gave 5.6 g of the desired product as a gummy solid, mp: 79°-89°. The IR and NMR were consistent with the proposed structure.

Workup

  1. customEvaporation of the mixture
  2. customto dryness and recrystallization of the residue from ethanolether

Sources & evidence

ORD record
ord-de7a3c82ec4a42599a0984958372f6a1
Source dataset
uspto-grants-1982_03
Patent number
US04321200

Reaction notes

Loading…