Hydrochloric Acid → 4,5-Dimethylthiazol-2-ylcarbamoylcarboxylic Acid

Participants

Reaction Steps

Ethyl 4,5-dimethylthiazol-2-ylcarbamoylcarboxylate (1.2 g., 5.26 mmole) was slurried in 40 ml. of water. Potassium carbonate (1 N, 5.3 ml., 2.65 mmoles) was added and the mixture heated on a steam bath for 5 minutes, yielding a clear solution. The reaction mixture was cooled in an ice-water bath and 6 ml. of 1 N hydrochloric acid added. The precipitated crude product was recovered by filtration (933 mg.). Recrystallization from acetic acid gave purified 4,5-dimethylthiazol-2-ylcarbamoylcarboxylic acid [652 mg.; m.p. 235°-236° C. (dec.)].

Provenance & Evidence