Hydrochloric Acid → HCID 12831785, compound

HRID 2059054Notes

Reaction equation

HRID 2059054 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:8][C:9]([C:11]([O:13]CC)=[O:12])=[O:10])[S:5][C:6]=1[CH3:7].C(=O)([O-])[O-].[K+].[K+].Cl>O>[CH3:1][C:2]1[N:3]=[C:4]([NH:8][C:9]([C:11]([OH:13])=[O:12])=[O:10])[S:5][C:6]=1[CH3:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 12831776HCID 12831776, compound

Product 1

HCID 12831785HCID 12831785, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 4,5-dimethylthiazol-2-ylcarbamoylcarboxylate (1.2 g., 5.26 mmole) was slurried in 40 ml. of water. Potassium carbonate (1 N, 5.3 ml., 2.65 mmoles) was added and the mixture heated on a steam bath for 5 minutes, yielding a clear solution. The reaction mixture was cooled in an ice-water bath and 6 ml. of 1 N hydrochloric acid added. The precipitated crude product was recovered by filtration (933 mg.). Recrystallization from acetic acid gave purified 4,5-dimethylthiazol-2-ylcarbamoylcarboxylic acid [652 mg.; m.p. 235°-236° C. (dec.)].

Workup

  1. temperaturethe mixture heated on a steam bath for 5 minutes
  2. customyielding a clear solution
  3. temperatureThe reaction mixture was cooled in an ice-water bath
  4. customThe precipitated crude product
  5. filtrationwas recovered by filtration (933 mg.)
  6. customRecrystallization from acetic acid
  7. customgave
  8. custompurified 4,5-dimethylthiazol-2-ylcarbamoylcarboxylic acid [652 mg.; m.p. 235°-236° C. (dec.)]

Sources & evidence

ORD record
ord-c0169741e1184e5f860558b185615be6
Source dataset
uspto-grants-1982_03
Patent number
US04321372

Reaction notes

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