Benzene → HCID 13363481, compound

HRID 2059114Notes

Reaction equation

HRID 2059114 reaction equation
C1C=CC=CC=1.[Cl:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[C:9]=1[CH:15]1[NH:19][CH2:18][CH2:17][S:16]1.[Cl:20][CH2:21][C:22](Cl)=[O:23]>C(N(CC)CC)C>[Cl:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([Cl:7])[C:9]=1[CH:15]1[N:19]([C:22](=[O:23])[CH2:21][Cl:20])[CH2:18][CH2:17][S:16]1

Participants

5

Reactant 3

HCID 241Benzene2×HCID 6577Chloroacetyl chlorideHCID 20221967HCID 20221967, compound

Product 1

HCID 13363481HCID 13363481, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Twenty-three and five tenths (23.5) ml. of a benzene solution containing 5.9 g. of 2(2',6'-dichlorophenyl) thiazolidine was combined with 25 ml. of benzene and 2.8 g. of chloroacetyl chloride and the mixture stirred in an ice bath, while 2.6 g. of triethylamine was added dropwise. After standing for about 30 minutes the mixture was washed with water, separated, dried over magnesium sulfate and the benzene stripped off under vacuum. There was obtained a yield of 8 g. of an oil, the title compound, ND30 =1.6041.

Workup

  1. washthe mixture was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 8 g

Sources & evidence

ORD record
ord-7537e49a035c4fdcb9b0f70459ebe091
Source dataset
uspto-grants-1982_03
Patent number
US04322240

Reaction notes

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