反应详情

1,800 g of 50% strength sodium hydroxide solution, 900 g of sodium hydroxide in the form of flakes and 300 g of methyl chloride are initially introduced into a pressure kettle provided with an anchor stirrer. 1,760 g of N-α-methoxyethyl-acetamide and 1,000 g of methyl chloride are uniformly metered in over a period of 3 hours. After a further 3 hours, the kettle is depressurized and the contents are degassed by passing in nitrogen. The reaction product with a lower specific gravity is separated from the inorganic constituents with a higher specific gravity in a centrifuge, and the reaction product is decanted off and distilled in vacuo. 1,804 g (91% of theory) of N-α-methoxyethyl-N-methylacetamide of boiling point1.0 48° are obtained.

1. customprovided with an anchor stirrer
2. customare uniformly metered in over a period of 3 hours
3. customthe contents are degassed
4. customThe reaction product with a lower specific gravity is separated from the inorganic constituents with a higher specific gravity in a centrifuge
5. customthe reaction product is decanted off
6. distillationdistilled in vacuo
7. customof boiling point1.0 48°
8. customare obtained