HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 17,21-Diacetoxy-6-methylene-4-pregnene-3,20-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 17,21-Bis(acetyloxy)pregn-4-ene-3,20-dione | HCID 102165 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dimethoxymethane | HCID 8020 | — |
| Product | 17,21-Diacetoxy-6-methylene-4-pregnene-3,20-dione | HCID 12951771 | 58.9% |
Reaction Steps
A solution of 2.0 g of 17,21-diacetoxy-4-pregnene-3,20-dione in 60 ml of methylene chloride and 60 ml of formaldehyde dimethylacetal is refluxed for 30 hours with 2.0 g of sodium acetate and 12.6 g of phosphorus pentachloride. The mixture is worked up analogously to Example 9, thus isolating 1.21 g of 17,21-diacetoxy-6-methylene-4-pregnene-3,20-dione, mp 227°-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04322349 |
| Source dataset | uspto-grants-1982_03 |
| ORD ID | ord-61426a9f0186448ba939e3e6c6b2426c |
| Source note | uspto-grants-1982_03 |