HRID2059162

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24819

Phosphorus pentachloride

Cl5P

结构：CC(=O)OCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

HCID102165

17,21-Bis(acetyloxy)pregn-4-ene-3,20-dione

C25H34O6

HCID517045

Sodium Acetate

C2H3NaO2

PRODUCTS

生成物

结构：C=C1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@]3(OC(C)=O)C(=O)COC(C)=O)[C@@]2(C)CCC(=O)C=C12

HCID12951771

未命名化合物

收率 58.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID8020

Dimethoxymethane

C3H8O2

PROCEDURE

实验过程

A solution of 2.0 g of 17,21-diacetoxy-4-pregnene-3,20-dione in 60 ml of methylene chloride and 60 ml of formaldehyde dimethylacetal is refluxed for 30 hours with 2.0 g of sodium acetate and 12.6 g of phosphorus pentachloride. The mixture is worked up analogously to Example 9, thus isolating 1.21 g of 17,21-diacetoxy-6-methylene-4-pregnene-3,20-dione, mp 227°-228° C.