Acrylic Acid → HCID 20546022, compound

HRID 2059171Notes

Reaction equation

HRID 2059171 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:17])([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][C:3]=1[SH:18].[C:19](O)(=[O:22])[CH:20]=[CH2:21]>>[F:16][C:13]([F:14])([F:15])[C:8]([C:5]1[CH:6]=[CH:7][C:2]2[NH:1][C:19](=[O:22])[CH2:20][CH2:21][S:18][C:3]=2[CH:4]=1)([OH:17])[C:9]([F:10])([F:11])[F:12]

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 13036817HCID 13036817, compound

Product 1

HCID 20546022HCID 20546022, compound

Procedure

To 4-amino-3-mercapto[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzene is added acrylic acid. The reaction mixture can be heated in a nitrogen atmosphere until analysis by thin layer chromatography indicates the reaction to complete. The residual material can be chromatographed and recrystallized to give 2,3-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]1,5-benzothiazepin-4(5H)-one

Workup

  1. temperatureThe reaction mixture can be heated in a nitrogen atmosphere until analysis by thin layer chromatography
  2. customthe reaction
  3. customThe residual material can be chromatographed
  4. customrecrystallized

Sources & evidence

ORD record
ord-38dab3e5400849149785fc39df7793aa
Source dataset
uspto-grants-1982_03
Patent number
US04322417

Reaction notes

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