Acrylic Acid → HCID 20546022, compound

Participants

Reaction Steps

To 4-amino-3-mercapto[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzene is added acrylic acid. The reaction mixture can be heated in a nitrogen atmosphere until analysis by thin layer chromatography indicates the reaction to complete. The residual material can be chromatographed and recrystallized to give 2,3-dihydro-8-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]1,5-benzothiazepin-4(5H)-one

Provenance & Evidence