Hydrogen Peroxide → HCID 13034535, compound

HRID 2059210Notes

Reaction equation

HRID 2059210 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH2:13][C:14]#[N:15])[CH2:10][C:11]#[N:12])[CH:6]=[CH:7][CH:8]=1.[OH2:16].[OH:17]O.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH2:10][C:11]([NH2:12])=[O:17])[CH2:13][C:14]([NH2:15])=[O:16])[CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 10340Sodium CarbonateHCID 13034527HCID 13034527, compound

Product 1

HCID 13034535HCID 13034535, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A sample of 18.7 g of 3-(3-methoxyphenyl)glutaronitrile prepared according to Preparation A, Part 3, is dissolved in 250 ml of acetone. This solution is stirred in an ice-bath and added are 125 ml of water, 40 ml of 30% hydrogen peroxide and 25 ml of 10% sodium carbonate. The mixture is allowed to stand at room temperature over night and is then concentrated to a volume of about 125 ml. The residue is cooled and the resulting crystalline precipitate is collected, washed with water and dried under vacuum to give 17.4 g of 3-(3-methoxyphenyl)glutaramide, mp 161°-162°.

Workup

  1. customaccording to Preparation A, Part 3
  2. additionadded
  3. waitto stand at room temperature over night
  4. concentrationis then concentrated to a volume of about 125 ml
  5. temperatureThe residue is cooled
  6. customthe resulting crystalline precipitate is collected
  7. washwashed with water
  8. customdried under vacuum

Sources & evidence

ORD record
ord-f35fad81e0584bddbecaeaac229a651c
Source dataset
uspto-grants-1982_03
Patent number
US04322421

Reaction notes

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