Ammonium Hydroxide → 5-(4-Chlorophenyl)-3-isoxazolecarboxamide

HRID 2059222ノート

反応式

HRID 2059222 の反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[O:8][N:7]=1)=O)C.[OH-].[NH4+:19]>>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:8][N:7]=[C:6]([C:4]([NH2:19])=[O:3])[CH:10]=2)=[CH:12][CH:13]=1

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 13035537Ethyl 5-(4-chlorophenyl)-1,2-oxazole-3-carboxylate

生成物 1

HCID 130355385-(4-Chlorophenyl)-3-isoxazolecarboxamide

実験手順

Ethyl-5-(4-chlorophenyl)-3-isoxazolecarboxylate (139 grams) and 1.5 l. of conc. aqueous ammonium hydroxide were placed in a 2 l. 3-necked flask and stirred with a mechanical stirrer for 3 days. Following this, the reaction mixture was poured into 2 l. of water, filtered, and washed with water. The resulting dry solid was swirled with 1.6 l. of chloroform for 1/2 hour, filtered, and then dried in a vacuum oven for 3 hours, m.p. 224°-225° C.

後処理

  1. additionwas poured into 2 l
  2. filtrationof water, filtered
  3. washwashed with water
  4. customThe resulting dry solid
  5. waitof chloroform for 1/2 hour
  6. filtrationfiltered
  7. customdried in a vacuum oven for 3 hours

出典と根拠

ORDレコード
ord-b4715ee3d3d64a35b59f5d13524ffe2a
出典データセット
uspto-grants-1982_03
特許番号
US04322429

反応ノート

読み込み中…