Ammonium Hydroxide → 5-(4-Chlorophenyl)-3-isoxazolecarboxamide

Participants

Reaction Steps

Ethyl-5-(4-chlorophenyl)-3-isoxazolecarboxylate (139 grams) and 1.5 l. of conc. aqueous ammonium hydroxide were placed in a 2 l. 3-necked flask and stirred with a mechanical stirrer for 3 days. Following this, the reaction mixture was poured into 2 l. of water, filtered, and washed with water. The resulting dry solid was swirled with 1.6 l. of chloroform for 1/2 hour, filtered, and then dried in a vacuum oven for 3 hours, m.p. 224°-225° C.

Provenance & Evidence