2,6-Dichlorobenzoyl chloride → HCID 13035562, compound

HRID 2059224Notes

Reaction equation

HRID 2059224 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([NH2:13])[CH:9]=2)=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:16]=1[C:17](Cl)=[O:18]>C1(C)C=CC=CC=1>[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[C:16]=1[C:17]([N:13]([C:17](=[O:18])[C:16]1[C:15]([Cl:14])=[CH:23][CH:22]=[CH:21][C:20]=1[Cl:24])[C:10]1[CH:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[O:12][N:11]=1)=[O:18]

Participants

4

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 13035539JR-9574, 5-(4-Chlorophenyl)isoxazol-3-amine, 97%

Product 1

HCID 13035562HCID 13035562, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5-(4-Chlorophenyl)-3-aminoisoxazole (400 milligrams prepared according to the teaching of Examples 11-14) was added to 2,6-dichlorobenzoylchloride (430 milligrams) in 50 ml. toluene and refluxed for 48 hours. The solvent was then evaporated and ethyl alcohol added; upon subsequent heating and filtering the bis acylated product was recovered; m.p. 219°-223° C.

Workup

  1. customThe solvent was then evaporated
  2. additionethyl alcohol added
  3. temperatureupon subsequent heating
  4. filtrationfiltering the bis
  5. customwas recovered

Sources & evidence

ORD record
ord-eb3fd644dbe54897b09eff30d1dcb86d
Source dataset
uspto-grants-1982_03
Patent number
US04322429

Reaction notes

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