2,6-Dichlorobenzoyl chloride → 2,6-Dichloro-N-(3-benzisoxazolyl)benzamide

HRID 2059235Notes

Reaction equation

HRID 2059235 reaction equation
[NH2:1][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][N:3]=1.[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:13]=1[C:14](Cl)=[O:15]>C1(C)C=CC=CC=1>[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:13]=1[C:14]([NH:1][C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][N:3]=1)=[O:15]

Participants

4

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 27797491,2-Benzoxazol-3-amine

Product 1

HCID 205467542,6-Dichloro-N-(3-benzisoxazolyl)benzamide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Aminobenzisoxazole (2 gram), 2,6-dichlorobenzoylchloride (2 gram), and 50 ml. of toluene are heated at reflux for 16 hours. After evaporation of the solvent at reduced pressure, the resultant oily semi-solid is triturated with ether. The solid so formed is then washed with ether and water and constitutes the desired product.

Workup

  1. temperatureat reflux for 16 hours
  2. customAfter evaporation of the solvent at reduced pressure
  3. customthe resultant oily semi-solid is triturated with ether
  4. customThe solid so formed
  5. washis then washed with ether and water

Sources & evidence

ORD record
ord-4944d88c8d17409192df679111a9782c
Source dataset
uspto-grants-1982_03
Patent number
US04322429

Reaction notes

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