2,6-Dichlorobenzoyl chloride → HCID 20546750, compound

HRID 2059237Notes

Reaction equation

HRID 2059237 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[C:11]2[O:10][N:9]=[C:8]([NH2:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[Cl:15][C:16]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:17]=1[C:18](Cl)=[O:19]>C1(C)C=CC=CC=1>[Cl:15][C:16]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:17]=1[C:18]([NH:12][C:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:1])([F:13])[F:14])[C:11]=2[O:10][N:9]=1)=[O:19]

Participants

4

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 107744567-Trifluoromethyl-benzo[d]isoxazol-3-ylamine

Product 1

HCID 20546750HCID 20546750, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

7-(Trifluoromethyl)-3-aminobenzisoxazole (2 gram), 2,6-dichlorobenzoylchloride (2 gram), and 50 ml. of toluene are heated at reflux for 16 hours. After evaporation of the solvent at reduced pressure, the resultant oily semi-solid is triturated with ether. The solid so formed is then washed with ether and water and constitutes the desired product.

Workup

  1. temperatureat reflux for 16 hours
  2. customAfter evaporation of the solvent at reduced pressure
  3. customthe resultant oily semi-solid is triturated with ether
  4. customThe solid so formed
  5. washis then washed with ether and water

Sources & evidence

ORD record
ord-040ca746202f4b7a9c02a29f90e9d7e2
Source dataset
uspto-grants-1982_03
Patent number
US04322429

Reaction notes

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