HCID 15572222, compound → HCID 15572235, compound

HRID 2059283Notes

Reaction equation

HRID 2059283 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([OH:17])([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])[CH:5]=[C:4]([CH3:18])[C:3]=1[NH:19][CH2:20][C:21]([O:23]CC)=[O:22]>[OH-].[Na+]>[C:21]([CH2:20][NH:19][C:3]1[C:2]([CH3:1])=[CH:7][C:6]([C:8]([OH:17])([C:13]([F:15])([F:14])[F:16])[C:9]([F:10])([F:11])[F:12])=[CH:5][C:4]=1[CH3:18])([OH:23])=[O:22]

Participants

3

Reactant 1

HCID 15572222HCID 15572222, compound

Product 1

HCID 15572235HCID 15572235, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Dissolve ethyl N-[2,6-dimethyl-4-(hexafluoro-2-hydroxy-2-propyl)phenyl]glycinate (3.1 g, 8.3 mmol) in 25 ml 1.0 N NaOH. After 1 hour, add 25 ml 1.0 N NCl and extract with ethyl acetate. Dry and concentrate. Recrstyallize from chloroform-benzene to give the title compound as beige solid, m.p. 153°-155° C. dec.

Workup

  1. additionadd 25 ml 1.0 N NCl
  2. extractionextract with ethyl acetate
  3. customDry
  4. concentrationconcentrate

Sources & evidence

ORD record
ord-f27b20042eb249fdb36690d0a6f500d6
Source dataset
uspto-grants-1982_03
Patent number
US04322434

Reaction notes

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