Trimethylsilyl iodide → HCID 178461812, compound

HRID 20593Notes

Reaction equation

HRID 20593 reaction equation
C[Si](I)(C)C.C[O:7][CH2:8][C@H:9]([CH3:38])[O:10][C:11]1[CH:12]=[C:13]([CH:23]=[C:24]([O:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:37]=[CH:36][NH:35][N:34]=3)=[CH:29][CH:28]=2)[CH:25]=1)[C:14]([NH:16][C:17]1[CH:21]=[CH:20][N:19]([CH3:22])[N:18]=1)=[O:15]>C(#N)C.C(OCC)(=O)C>[OH:7][CH2:8][C@H:9]([CH3:38])[O:10][C:11]1[CH:12]=[C:13]([CH:23]=[C:24]([O:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH:37]=[CH:36][NH:35][N:34]=3)=[CH:29][CH:28]=2)[CH:25]=1)[C:14]([NH:16][C:17]1[CH:21]=[CH:20][N:19]([CH3:22])[N:18]=1)=[O:15]

Participants

5

Reactant 2

HCID 85247Trimethylsilyl iodideHCID 178495720HCID 178495720, compound

Product 1

HCID 178461812HCID 178461812, compoundYield 82.4%

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 8857Ethyl AcetateSolvent

Procedure

Trimethylsilyl iodide (0.080 mL, 0.559 mmol) was added to a solution of 3-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-5-[4-(1H-pyrazol-3-yl)phenoxy]benzamide (50 mg, 0.112 mmol) in acetonitrile (2 mL) and the reaction mixture allowed to stir at RT for 18 hours. The reaction was diluted with ethyl acetate (15 mL) and quenched by the addition of saturated aqueous sodium bicarbonate solution (20 mL). The organic phase was washed with saturated aqueous thiosulphate solution (20 mL) and dried (MgSO4). The volatiles were removed under reduced pressure and the resulting oil purified by chromatography on silica, eluting with 0-100% ethyl acetate in iso-hexane, to give the title compound as a colourless solid (40 mg).

Workup

  1. customquenched by the addition of saturated aqueous sodium bicarbonate solution (20 mL)
  2. washThe organic phase was washed with saturated aqueous thiosulphate solution (20 mL)
  3. dry with materialdried (MgSO4)
  4. customThe volatiles were removed under reduced pressure
  5. customthe resulting oil purified by chromatography on silica
  6. washeluting with 0-100% ethyl acetate in iso-hexane

Sources & evidence

ORD record
ord-20f74b77b8874046b1223d2344295153
Source dataset
uspto-grants-2010_06
Patent number
US07745475B2

Reaction notes

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