反应详情

Aluminium chloride (15.5 g) was added over 2 hours in small portions to an ice-cooled solution of 3-trifluoromethylbenzoyl chloride (21.7 g) and anisole (12.5 g) in dichloromethane. After a further 2 hours at room temperature, the mixture was poured on to ice, extracted with dichloromethane and the extracts washed with water and dried (MgSO4). Removal of solvent gave a solid which was recrystallised first from light petrol (b.p. 60°-80°) and then from ethanol-water, giving white prisms of the ketone, m.p. 62.5°-63.5°, (17.5 g, 60%).

1. additionthe mixture was poured on to ice
2. extractionextracted with dichloromethane
3. washthe extracts washed with water
4. dry with materialdried (MgSO4)
5. customRemoval of solvent
6. customgave a solid which
7. customwas recrystallised first from light petrol (b.p. 60°-80°)