Epichlorohydrin → HCID 20545914, compound

HRID 2059325Notes

Reaction equation

HRID 2059325 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:19])=[CH:16][CH:17]=3)[C:12](=[O:20])[C:11]([CH3:22])([CH3:21])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].[CH2:23]([CH:25]1[O:27][CH2:26]1)Cl.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([O:19][CH2:23][CH:25]4[O:27][CH2:26]4)=[CH:16][CH:17]=3)[C:12](=[O:20])[C:11]([CH3:22])([CH3:21])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 20545912HCID 20545912, compound

Product 1

HCID 20545914HCID 20545914, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 4-(3,4-dichlorophenyl)-7-hydroxy-2,2-dimethyl-1-tetralone (2.9 g), epichlorohydrin (10 ml) and potassium carbonate (2 g) was heated under reflux in acetone (10 ml) for 24 hr. The hot mixture was filtered and evaporation of the filtrate in vacuo gave 4-(3,4-dichlorophenyl)-7-(2,3-epoxypropoxy)-2,2-dimethyl-1-tetralone as a yellow gum (3.2 g, 94%).

Workup

  1. temperaturewas heated
  2. filtrationThe hot mixture was filtered
  3. customevaporation of the filtrate in vacuo

Sources & evidence

ORD record
ord-a39801c479334689aefcb0ea9d6e834d
Source dataset
uspto-grants-1982_03
Patent number
US04322370

Reaction notes

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