Hydrazine hydrate (1:1) → HCID 178495720, compound

HRID 20594Notes

Reaction equation

C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:34]=[CH:33][C:10]([O:11][C:12]2[CH:13]=[C:14]([CH:24]=[C:25]([O:27][C@@H:28]([CH3:32])[CH2:29][O:30][CH3:31])[CH:26]=2)[C:15]([NH:17][C:18]2[CH:22]=[CH:21][N:20]([CH3:23])[N:19]=2)=[O:16])=[CH:9][CH:8]=1)=O.O.[NH2:37]N>C(O)C>[CH3:31][O:30][CH2:29][C@H:28]([CH3:32])[O:27][C:25]1[CH:24]=[C:14]([CH:13]=[C:12]([O:11][C:10]2[CH:33]=[CH:34][C:7]([C:5]3[CH:4]=[CH:3][NH:2][N:37]=3)=[CH:8][CH:9]=2)[CH:26]=1)[C:15]([NH:17][C:18]1[CH:22]=[CH:21][N:20]([CH3:23])[N:19]=1)=[O:16]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide (100 mg, 0.209 mmol) and hydrazine hydrate (0.204 mL, 4.18 mmol) in ethanol (3 mL) was heated to 100° C. for 5 minutes in a ‘Smith Creator’ microwave. The volatiles were removed in vacuo to give the product as a colourless foam (92 mg).

Workup

customThe volatiles were removed in vacuo

Sources & evidence

ORD record: ord-0e8636f8260340669843fe41b68014d9
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07745475B2

Reaction notes

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