4-Methoxybenzaldehyde → z-Methyl-2-chloro-3-(4'-methoxyphenyl)propenoate

HRID 2059427Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059427
COc1ccc(C=O)cc1.COC(=O)C(Cl)C(=O)O>C1CCNC1.CN(C)c1ccncc1.C1CCOC1>COC(=O)/C(Cl)=C/c1ccc(OC)cc1

Komponenten

6

Edukt 2

HCID 312444-MethoxybenzaldehydeHCID 17909959HCID 17909959, Verbindung

Produkt 1

HCID 12339865z-Methyl-2-chloro-3-(4'-methoxyphenyl)propenoateAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 142844-(Dimethylamino)pyridineReagenzHCID 31268PyrrolidineKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Aufarbeitung

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Organic-Phase beibehalten
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Quellen und Nachweise

ORD-Eintrag
ord-bda7127add26421188425ad929fa4182
Quelldatensatz
Transfer learning optimization of 26 decarboxylative olefination reactions

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