4-Iodobenzaldehyde → HCID 6426405, compound

HRID 2059446Notes

Reaction equation

HRID 2059446 reaction equation
O=Cc1ccc(I)cc1.CCOC(=O)C(Cl)C(=O)O>C1COCCN1.CN(C)c1ccncc1.Cc1ccccc1>CCOC(=O)/C(Cl)=C/c1ccc(I)cc1

Participants

6

Reactant 2

HCID 966574-IodobenzaldehydeHCID 13526827HCID 13526827, compound

Product 1

HCID 6426405HCID 6426405, compoundYield 38%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 8083MorpholineCatalystHCID 1140TolueneSolvent

Conditions

Temperature
25 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-d6bd8b58560c423c8f626dbb235da6c8
Source dataset
Transfer learning optimization of 26 decarboxylative olefination reactions

Reaction notes

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