Hydrochloric Acid → HCID 45264782, compound

HRID 2059740Notes

Reaction equation

HRID 2059740 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.[N:7]#[C:8][NH2:9].[ClH:10].O1CCOCC1>CCOCC>[ClH:10].[CH3:1][C:2]1[CH:3]=[N:4][N:5]([C:8](=[NH:7])[NH2:9])[CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 34064-MethylpyrazoleHCID 9864CyanamideHCID 312751,4-Dioxane

Product 1

HCID 45264782HCID 45264782, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
110 °C

Procedure

To 4-Methyl-1H-pyrazole (4.9 g, 60 mmol) was added cyanamide (2.5 g, 60 mmol), HCl (5.6 mL, 62 mmol, 4 M in dioxane) and dioxane (60 mL). The reaction was heated to 110° C. and aged for 9 h. It was then aged at rt overnight. The mixture was diluted with Et2O and stirred for 10 min. The product was isolated by filtration and washed with Et2O to afford the title compound.

Workup

  1. customThe product was isolated by filtration
  2. washwashed with Et2O

Sources & evidence

ORD record
ord-d7ecd80cf44143899b0a1c6d2654cb68
Source dataset
uspto-grants-2012_10
Patent number
US08278304B2

Reaction notes

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