Trifluoroacetic acid → HCID 178457734, compound

HRID 2059742Notes

Reaction equation

HRID 2059742 reaction equation
[OH:1][C:2]1[C:7]([C:8]([NH:10][C:11]([CH3:20])([C:13]([O:15]C(C)(C)C)=[O:14])[CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([N:21]2[CH:25]=[CH:24][CH:23]=[N:22]2)[N:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[OH:1][C:2]1[C:7]([C:8]([NH:10][C:11]([CH3:12])([C:13]([OH:15])=[O:14])[CH3:20])=[O:9])=[CH:6][N:5]=[C:4]([N:21]2[CH:25]=[CH:24][CH:23]=[N:22]2)[N:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178451041HCID 178451041, compound

Product 1

HCID 178457734HCID 178457734, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Step A (3.0 g, 8.64 mmol) was combined with DCM (18 ml) and TFA (2.5 mL). The reaction was aged at reflux for about 5 h and then concentrated. The product was then treated with Et2O, isolated by filtration, and washed with hexane to afford the title compound. HPLC/MS: 292.0 (M+1); Rt=1.42 min.

Workup

  1. temperatureat reflux for about 5 h
  2. concentrationconcentrated
  3. additionThe product was then treated with Et2O
  4. customisolated by filtration
  5. washwashed with hexane

Sources & evidence

ORD record
ord-1d308b88f7ca4cca9cbe3f515648251e
Source dataset
uspto-grants-2012_10
Patent number
US08278304B2

Reaction notes

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