N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide → 5-[5-(3-imidazol-1-yl-5-trifluoromethylphenylcarbamoyl)-2-methyl-phenylethynyl]-1-methyl-1H-imidazole-2-carboxylic acid amide

HRID 2059790Notes

Reaction equation

HRID 2059790 reaction equation
[C:1]([C:3]1[N:7]([CH3:8])[C:6]([C:9]([NH2:11])=[O:10])=[N:5][CH:4]=1)#[CH:2].[N:12]1([C:17]2[CH:18]=[C:19]([NH:27][C:28](=[O:37])[C:29]3[CH:34]=[CH:33][C:32]([CH3:35])=[C:31](I)[CH:30]=3)[CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=2)[CH:16]=[CH:15][N:14]=[CH:13]1>>[N:12]1([C:17]2[CH:18]=[C:19]([NH:27][C:28]([C:29]3[CH:30]=[CH:31][C:32]([CH3:35])=[C:33]([C:2]#[C:1][C:3]4[N:7]([CH3:8])[C:6]([C:9]([NH2:11])=[O:10])=[N:5][CH:4]=4)[CH:34]=3)=[O:37])[CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:22]=2)[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

3

Reactant 2

HCID 44222638N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamideHCID 577374055-Ethynyl-1-methyl-1h-imidazole-2-carboxamide

Product 1

HCID 248629575-[5-(3-imidazol-1-yl-5-trifluoromethylphenylcarbamoyl)-2-methyl-phenylethynyl]-1-methyl-1H-imidazole-2-carboxylic acid amide

Procedure

This was made as for example 2 using 5-ethynyl-1-methyl-1H-imidazole-2-carboxylic acid amide and N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide: MS (M+H)+ 493.

Sources & evidence

ORD record
ord-cf7be1f5927f4b7ebea61187c1177f1e
Source dataset
uspto-grants-2012_10
Patent number
US08278307B2

Reaction notes

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