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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2059790Generated: November 2, 2026

N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide → 5-[5-(3-imidazol-1-yl-5-trifluoromethylphenylcarbamoyl)-2-methyl-phenylethynyl]-1-methyl-1H-imidazole-2-carboxylic acid amide

https://huagongshe.com/reaction/2059790

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamideHCID 44222638—
Reactant5-Ethynyl-1-methyl-1h-imidazole-2-carboxamideHCID 57737405—
Product5-[5-(3-imidazol-1-yl-5-trifluoromethylphenylcarbamoyl)-2-methyl-phenylethynyl]-1-methyl-1H-imidazole-2-carboxylic acid amideHCID 24862957—

Reaction Steps

This was made as for example 2 using 5-ethynyl-1-methyl-1H-imidazole-2-carboxylic acid amide and N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide: MS (M+H)+ 493.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08278307B2
Source datasetuspto-grants-2012_10
ORD IDord-cf7be1f5927f4b7ebea61187c1177f1e
Source noteuspto-grants-2012_10