HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Isothiocyanatoisoquinoline → (3R*,4S*)-N-(isoquinolin-3-yl)-4'H-1-azaspiro[bicyclo[2.2.1]heptane-3,5'-oxazol]-2'-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Isothiocyanatoisoquinoline | HCID 57476565 | — |
| Reactant | (3S*,4S*)-3-(aminomethyl)-1-azabicyclo[2.2.1]heptan-3-ol dihydrochloride | HCID 57516883 | — |
| Product | (3R*,4S*)-N-(isoquinolin-3-yl)-4'H-1-azaspiro[bicyclo[2.2.1]heptane-3,5'-oxazol]-2'-amine | HCID 52912200 | 26% |
Reaction Steps
3-Isothiocyanatoisoquinoline and (3S*,4S*)-3-(aminomethyl)-1-azabicyclo[2.2.1]heptan-3-ol dihydrochloride were reacted according to the method of EXAMPLE 6, STEP B to afford (3R*,4S*)—N-(isoquinolin-3-yl)-4′H-1-azaspiro[bicyclo[2.2.1]heptane-3,5′-oxazol]-2′-amine (80 mg, 0.27 mmol, 26% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08278320B2 |
| Source dataset | uspto-grants-2012_10 |
| ORD ID | ord-137f85e73f2d40b0b50b3cb3124df2db |
| Source note | uspto-grants-2012_10 |