HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2059847Generated: November 1, 2026
Tributyl(2-phenylethynyl)stannane → HCID 178517722, compound
https://huagongshe.com/reaction/2059847
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributyl(2-phenylethynyl)stannane | HCID 630640 | — |
| Reactant | 2-Oxo-1-trityl-1,2-dihydropyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate | HCID 58579886 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178517722 | HCID 178517722 | — |
Reaction Steps
Tributyl(phenylethynyl)stannane (315 mg, 0.8 mmol) was added to a stirred solution of 2-oxo-1-trityl-1,2-dihydropyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate Part A (200 mg, 0.3 mmol), copper (I) iodide (18.4 mg, 0.1 mmol) and palladium tetrakis (55.8 mg, 0.05 mmol) in 5 mL DMF under nitrogen. The reaction mixture was heated at 55° C. for 16 h, concentrated and subjected to flash chromatography (silica gel/methylene chloride to 15% MeOH-methylene chloride gradient to afford 4-(phenylethynyl)pyrimidin-2(1H)-one 4B (66 mg) as a brownish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08278316B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-029522b1c85d447bbff0fdaa0fb8b00e |
|---|
| Source note | uspto-grants-2012_10 |
|---|
