反应详情

温度

55 °C

Tributyl(phenylethynyl)stannane (315 mg, 0.8 mmol) was added to a stirred solution of 2-oxo-1-trityl-1,2-dihydropyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate Part A (200 mg, 0.3 mmol), copper (I) iodide (18.4 mg, 0.1 mmol) and palladium tetrakis (55.8 mg, 0.05 mmol) in 5 mL DMF under nitrogen. The reaction mixture was heated at 55° C. for 16 h, concentrated and subjected to flash chromatography (silica gel/methylene chloride to 15% MeOH-methylene chloride gradient to afford 4-(phenylethynyl)pyrimidin-2(1H)-one 4B (66 mg) as a brownish solid.

1. concentrationconcentrated