反应详情

温度

25 °C

tetra-n-Butylammonium chloride (0.33 eq) and 35% sodium hydroxide solution (18 ml) were added to a solution of N-cyclopropyl-N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylphenylsulfonamide (3.3 mmol) in toluene (18 ml), cooled to 0° C. tert-Butylbromoacetate (1.5 eq) was added slowly to this mixture at 0° C. On completion of the addition the mixture was stirred for 90 min at 25° C. until the reaction was complete. The organic phase was separated off, washed with water until a neutral pH was measured, dried over MgSO4, filtered and concentrated completely to obtain the desired product. Yield: 90%

1. additionwas added slowly to this mixture at 0° C
2. additionOn completion of the addition the mixture
3. customThe organic phase was separated off
4. washwashed with water until a neutral pH
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. concentrationconcentrated completely