Trifluoroacetic acid → 2-(2-(N-Cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetic acid

HRID 2059886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2059886
FC(F)(F)C(O)=O.[CH:8]1([N:11]([CH2:25][CH2:26][O:27][CH2:28][C:29]([O:31]C(C)(C)C)=[O:30])[S:12]([C:15]2[C:20]([CH3:21])=[CH:19][C:18]([O:22][CH3:23])=[CH:17][C:16]=2[CH3:24])(=[O:14])=[O:13])[CH2:10][CH2:9]1>ClCCl>[CH:8]1([N:11]([CH2:25][CH2:26][O:27][CH2:28][C:29]([OH:31])=[O:30])[S:12]([C:15]2[C:20]([CH3:21])=[CH:19][C:18]([O:22][CH3:23])=[CH:17][C:16]=2[CH3:24])(=[O:14])=[O:13])[CH2:9][CH2:10]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 59820154tert-butyl 2-(2-(N-cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetate

Produkt 1

HCID 598201282-(2-(N-Cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

Trifluoroacetic acid (13 eq) was added dropwise to a solution of tert-butyl 2-(2-(N-cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetate in dichloromethane (10 ml/mmol) at 0° C. and the resulting solution was stirred for 2 h at 25° C. The mixture was concentrated completely and traces of trifluoroacetic acid removed under high vacuum. The crude product was used directly in the next stage with no further processing.

Aufarbeitung

  1. concentrationThe mixture was concentrated completely
  2. customremoved under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-24df7faa184445d6950e54a127aed3e9
Quelldatensatz
uspto-grants-2012_10
Patentnummer
US08278319B2

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