HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2059886Generated: October 25, 2026
Trifluoroacetic acid → 2-(2-(N-Cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetic acid
https://huagongshe.com/reaction/2059886
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 2-(2-(N-cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetate | HCID 59820154 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2-(N-Cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetic acid | HCID 59820128 | — |
Reaction Steps
Trifluoroacetic acid (13 eq) was added dropwise to a solution of tert-butyl 2-(2-(N-cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetate in dichloromethane (10 ml/mmol) at 0° C. and the resulting solution was stirred for 2 h at 25° C. The mixture was concentrated completely and traces of trifluoroacetic acid removed under high vacuum. The crude product was used directly in the next stage with no further processing.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08278319B2 |
|---|
| Source dataset | uspto-grants-2012_10 |
|---|
| ORD ID | ord-24df7faa184445d6950e54a127aed3e9 |
|---|
| Source note | uspto-grants-2012_10 |
|---|
