反应详情

4-Methoxy-2,6-dimethylbenzenesulfonic acid chloride (3.83 mmol, 1.0 eq) in DCM (5 ml) was added dropwise to a cooled (0° C.) solution of (S)-indolin-2-ylmethanol (4.60 mmol, 1.2 eq) and triethylamine (2.5 eq) in DCM (20 ml) and the mixture was stirred for 2 h at room temperature. The reaction mixture was diluted with DCM and washed with water and saturated sodium chloride solution. It was dried over sodium sulfate and concentrated to small volume under vacuum. The crude product was processed by column chromatography. Yield: 72%

1. washwashed with water and saturated sodium chloride solution
2. dry with materialIt was dried over sodium sulfate
3. concentrationconcentrated to small volume under vacuum