Lithium Hydroxide → 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propionic Acid

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Reaction Conditions

Reaction Steps

Methanol/H2O (3:1, 90 ml) was added to 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propionic acid ethyl ester (3.48 g, 9 mmol) at 25° C., the mixture was cooled to 0° C., lithium hydroxide (0.75 g, 18 mmol) was added, and the mixture was stirred for 16 h at 25° C. The solvent was removed under vacuum, the residue taken up in water and washed with dichloromethane. The aqueous phase was carefully acidified with hydrogen chloride solution (1 mol/l) and extracted with ethyl acetate. This organic phase was washed with water and saturated sodium chloride solution, dried over sodium sulfate and concentrated to small volume under vacuum. Yield: 89%

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