反应详情

温度

0 °C

Methanol/H2O (3:1, 90 ml) was added to 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propionic acid ethyl ester (3.48 g, 9 mmol) at 25° C., the mixture was cooled to 0° C., lithium hydroxide (0.75 g, 18 mmol) was added, and the mixture was stirred for 16 h at 25° C. The solvent was removed under vacuum, the residue taken up in water and washed with dichloromethane. The aqueous phase was carefully acidified with hydrogen chloride solution (1 mol/l) and extracted with ethyl acetate. This organic phase was washed with water and saturated sodium chloride solution, dried over sodium sulfate and concentrated to small volume under vacuum. Yield: 89%

1. customThe solvent was removed under vacuum
2. washwashed with dichloromethane
3. extractionextracted with ethyl acetate
4. washThis organic phase was washed with water and saturated sodium chloride solution
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated to small volume under vacuum