Trifluoroacetic acid → HCID 67315937, compound

HRID 2059901Notes

Reaction equation

HRID 2059901 reaction equation
C(O)(C(F)(F)F)=O.[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[CH:25]=[CH:24][NH:23][C:22](=[O:26])[C@@H:21]2[CH2:27][C:28]([O:30]C(C)(C)C)=[O:29])(=[O:19])=[O:18])=[C:12]([CH3:35])[CH:11]=1>C(Cl)Cl>[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[CH:25]=[CH:24][NH:23][C:22](=[O:26])[C@@H:21]2[CH2:27][C:28]([OH:30])=[O:29])(=[O:19])=[O:18])=[C:12]([CH3:35])[CH:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67315532HCID 67315532, compound

Product 1

HCID 67315937HCID 67315937, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (1.5 ml) was added to a cooled (0° C.) solution of (S)-tert-butyl 2-(1-(4-methoxy-2,6-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetate (210 mg, 1 eq) in DCM (6 ml) and the mixture was stirred for 2 h at room temperature. The solvent was removed under vacuum and the residue used in the subsequent stage.

Workup

  1. customThe solvent was removed under vacuum

Sources & evidence

ORD record
ord-40c2a9a5e3e44d3c9d328daf05909660
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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