反应详情

温度

25 °C

A mixture of 1,4-dioxaspiro[4.5]decan-8-one (10 g, 64 mmol), benzotriazole (7.62 g, 64 mmol) and pyrrolidine (5.26 ml, 64 mmol) in dry benzene (300 ml) was refluxed under an argon atmosphere in a water separator for 18 h. The reaction mixture was cooled to 25° C. and concentrated to small volume under vacuum and dried (aerated with argon). The crude product was taken up in dry tetrahydrofuran (50 ml) and cooled to 0° C. Phenyl magnesium bromide solution (650 ml, 1 mol/l in tetrahydrofuran) was added dropwise under protective gas. The cooling bath was removed and the mixture stirred for 18 h at 25° C. The reaction mixture was cooled to 0° C. again, hydrolysed with saturated ammonium chloride solution and extracted with ethyl acetate (3×300 ml). The combined organic phases were washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated to small volume under vacuum. The crude product was purified by column chromatography (silica gel) with 5% methanol in dichloromethane. Yield: 13%

1. concentrationconcentrated to small volume under vacuum
2. customdried (aerated with argon)
3. temperaturecooled to 0° C
4. additionPhenyl magnesium bromide solution (650 ml, 1 mol/l in tetrahydrofuran) was added dropwise under protective gas
5. customThe cooling bath was removed
6. temperatureThe reaction mixture was cooled to 0° C. again
7. extractionhydrolysed with saturated ammonium chloride solution and extracted with ethyl acetate (3×300 ml)
8. washThe combined organic phases were washed with saturated sodium chloride solution
9. dry with materialdried over sodium sulfate
10. filtrationfiltered
11. concentrationconcentrated to small volume under vacuum
12. customThe crude product was purified by column chromatography (silica gel) with 5% methanol in dichloromethane