1-(8-Phenyl-1,4-dioxaspiro[4.5]decan-8-yl)pyrrolidine → 4-Phenyl-4-(1-pyrrolidinyl)cyclohexanone

HRID 2059907Notes

Reaction equation

HRID 2059907 reaction equation
[C:1]1([C:7]2([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:16][CH2:15][C:10]3(OCC[O:11]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CN(C)C1(C2C=CC=CC=2)CCC2(CCNCC2)CC1>>[C:1]1([C:7]2([N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)[CH2:8][CH2:9][C:10](=[O:11])[CH2:15][CH2:16]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 133452641-(8-Phenyl-1,4-dioxaspiro[4.5]decan-8-yl)pyrrolidineHCID 59311794HCID 59311794, compound

Product 1

HCID 133452724-Phenyl-4-(1-pyrrolidinyl)cyclohexanoneYield 80%

Procedure

The reaction was performed starting from 1-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)pyrrolidine in an analogous manner to stage 2 amine (A1). Yield: 80%

Sources & evidence

ORD record
ord-bf402fceb8c443f297a0d3d8605fae96
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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