8-(3-fluorophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine → 4-(Dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

HRID 2059910Notes

Reaction equation

HRID 2059910 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2([N:18]([CH3:20])[CH3:19])[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.CN(C)C1(C2C=CC=CC=2)CCC2(CCNCC2)CC1>>[CH3:19][N:18]([CH3:20])[C:8]1([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH2:17][CH2:16][C:11](=[O:12])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 574751108-(3-fluorophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amineHCID 59311794HCID 59311794, compound

Product 1

HCID 574751114-(Dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

Procedure

The reaction was performed starting from 8-(3-fluorophenyl)-N,N-dimethyl-1,4-dioxaspiro[4.5]decan-8-amine in an analogous manner to stage 2 amine (A1).

Sources & evidence

ORD record
ord-145a57f1a8174b2683aed84a8b09cf43
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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