Trifluoroacetic acid → HCID 59311823, compound

Participants

Reaction Steps

tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate (300 mg, 0.714 mmol) was taken up in DCM (24 ml) and TFA (6 ml) was added. The resulting mixture was stirred for 3 h. The TLC revealed completion of the reaction and the solvent was removed under reduced pressure. The compound was azeotroped (2-3×) with DCM and used in the next step.

Provenance & Evidence