Trifluoroacetic acid → HCID 59311823, compound

HRID 2059922Notes

Reaction equation

HRID 2059922 reaction equation
[F:1][C:2]1([F:30])[CH2:5][N:4]([C:6]2([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:23][CH2:22][C:9]3([CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]3)[CH2:8][CH2:7]2)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:30][C:2]1([F:1])[CH2:5][N:4]([C:6]2([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:7][CH2:8][C:9]3([CH2:10][CH2:11][NH:12][CH2:13][CH2:14]3)[CH2:22][CH2:23]2)[CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86641305HCID 86641305, compound

Product 1

HCID 59311823HCID 59311823, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate (300 mg, 0.714 mmol) was taken up in DCM (24 ml) and TFA (6 ml) was added. The resulting mixture was stirred for 3 h. The TLC revealed completion of the reaction and the solvent was removed under reduced pressure. The compound was azeotroped (2-3×) with DCM and used in the next step.

Workup

  1. customcompletion of the reaction
  2. customthe solvent was removed under reduced pressure
  3. customThe compound was azeotroped (2-3×) with DCM

Sources & evidence

ORD record
ord-bf3a5582363540178282a2594f1612a6
Source dataset
uspto-grants-2012_10
Patent number
US08278319B2

Reaction notes

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