反应详情

A well stirred mixture of 100 mg (0.197 mmol) 1-[4′-(4,5-difluoro-2,3-dihydro-indole-1-carbonyl)-6′-methoxy-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one and 0.500 g (4.33 mmol) pyridine hydrochloride was kept in a melt for 7 min using a hot air blower. After the reaction had cooled the mixture was dissolved in DMF and purified by preparative HPLC. The product-containing fractions were combined and lyophilised.

1. temperatureAfter the reaction had cooled the mixture
2. custompurified by preparative HPLC