Pyridinium chloride → HCID 42613456, compound

HRID 2059985Notes

Reaction equation

HRID 2059985 reaction equation
[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:12]([C:14]1[CH:19]=[C:18]([O:20]C)[N:17]=[C:16]([N:22]2[CH2:27][CH2:26][CH:25]([N:28]3[C:36]4[C:31](=[N:32][CH:33]=[CH:34][CH:35]=4)[NH:30][C:29]3=[O:37])[CH2:24][CH2:23]2)[CH:15]=1)=[O:13].Cl.N1C=CC=CC=1>CN(C=O)C>[F:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:12]([C:14]1[CH:15]=[C:16]([N:22]2[CH2:27][CH2:26][CH:25]([N:28]3[C:36]4[C:31](=[N:32][CH:33]=[CH:34][CH:35]=4)[NH:30][C:29]3=[O:37])[CH2:24][CH2:23]2)[NH:17][C:18](=[O:20])[CH:19]=1)=[O:13]

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 426140901-[4'-(4,5-Difluoro-2,3-dihydro-indole-1-carbonyl)-6'-methoxy-3,4,5,6-tetra-hydro-2H-[1,2]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

Product 1

HCID 42613456HCID 42613456, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A well stirred mixture of 100 mg (0.197 mmol) 1-[4′-(4,5-difluoro-2,3-dihydro-indole-1-carbonyl)-6′-methoxy-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one and 0.500 g (4.33 mmol) pyridine hydrochloride was kept in a melt for 7 min using a hot air blower. After the reaction had cooled the mixture was dissolved in DMF and purified by preparative HPLC. The product-containing fractions were combined and lyophilised.

Workup

  1. temperatureAfter the reaction had cooled the mixture
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-656add44f1164751af1135d8d569ff46
Source dataset
uspto-grants-2012_10
Patent number
US08278336B2

Reaction notes

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