反应详情

A well stirred mixture of 40 mg (0.082 mmol) 1-[6′-(5-fluoro-2,3-dihydro-indole-1-carbonyl)-2′-methoxy-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-yl]-1,3-dihydro-imidazo-[4,5-b]pyridin-2-one and 0.020 g (1.7 mmol) pyridine hydrochloride was kept in a melt for 2 min using a hot air blower. After the reaction had cooled the mixture was dissolved in DMF and purified by preparative HPLC. The product-containing fractions were combined and lyophilised.

1. temperatureAfter the reaction had cooled the mixture
2. custompurified by preparative HPLC