HCID 2755516, compound → HCID 14520121, compound

HRID 2060038Notes

Reaction equation

HRID 2060038 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([N+:11]([O-])=O)[CH:5]=1>C(O)C.[Pt](=O)=O>[NH2:11][C:6]1[CH:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:9]=[CH:8][C:7]=1[OH:10]

Participants

4

Reactant 1

HCID 2755516HCID 2755516, compound

Product 1

HCID 14520121HCID 14520121, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[(methyloxy)methyl]-2-nitrophenol D119 (0.72 g, 3.93 mmol) and platinum (IV) oxide (0.089 g, 0.393 mmol) in ethanol (15 mL) was stirred under an atmosphere of hydrogen for 16 hr. The catalyst was removed by filtration through celite and the filtrate concentrated to dryness in vacuo to afford the title compound as a green/brown solid 0.51 g, 85%.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe filtrate concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-4d49b824423b417e8c5c6fbb85fc8082
Source dataset
uspto-grants-2012_10
Patent number
US08278328B2

Reaction notes

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