Sodium Hydroxide → HCID 68802039, compound

HRID 2060071Notes

Reaction equation

HRID 2060071 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=2)[C:7]1=[O:20])[CH3:4].[OH-].[Na+]>O>[CH3:4][N:3]([CH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:15][C:16]([F:19])([F:17])[F:18])[CH:12]=2)[C:7]1=[O:20])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 694507812-Dimethylaminomethyl-5-trifluoromethoxy-indan-1-one hydrochloride

Product 1

HCID 68802039HCID 68802039, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

14 g of the product from step 3 were dissolved in water; the solution was adjusted to pH 12 with 32% sodium hydroxide solution, while cooling with ice, and extracted three times with dichloromethane, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated in vacuo.

Workup

  1. temperaturewhile cooling with ice
  2. extractionextracted three times with dichloromethane
  3. dry with materialthe combined organic phases were dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-778622f470074d93814ea356c2bf25bd
Source dataset
uspto-grants-2012_10
Patent number
US08278338B2

Reaction notes

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