反应详情

5 g of (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine are added to a suspension of 0.666 g of magnesium hydroxide in 20 ml of water. 40 ml of methanol are added, then the mixture is stirred for 2 hours at room temperature and concentrated. The residue is dissolved in methanol, filtered through a hard filter, concentrated and evaporated with acetonitrile. The product is stirred with hot acetonitrile, filtered by suction at room temperature and dried in a high vacuum at 90° C. over night. (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amine magnesium salt is obtained as a white powder. Melting point: The sample becomes brownish upon heating and vitrifies towards 300° C.

1. concentrationconcentrated
2. dissolutionThe residue is dissolved in methanol
3. filtrationfiltered through a hard filter
4. concentrationconcentrated
5. customevaporated with acetonitrile
6. stirringThe product is stirred with hot acetonitrile
7. filtrationfiltered by suction at room temperature
8. customdried in a high vacuum at 90° C. over night